|
名稱 |
Mouse gp130 / IL6ST / CD130 Protein/重組小鼠 gp130 |
|
規(guī)格 |
20ug |
|
編號 |
CZDB-001 |
|
價格 |
詢價 |
|
中文名 |
重組小鼠 gp130 / IL6ST / CD130 蛋白 |
|
分子別稱 |
Ac1055, Gp130, Il-6rb |
|
分子種屬 |
Mouse |
|
表達(dá)標(biāo)簽 |
His，S |
|
表達(dá)宿主 |
E. coli |
|
濃度 |
> 95 % as determined by SDS-PAGE |
|
緩沖液 |
Lyophilized from sterile PBS, pH 7.4 |
|
存儲條件 |
-70°C，應(yīng)避免反復(fù)凍融。 |
|
基本描述 |
Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. CD130/gp130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and Oncostatin M (OSM). CD130/gp130 functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. CD130/gp130 plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. A related pseudogene has been identified on chromosome 17. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. CD130/gp130 binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. CD130/gp130 may have a role in embryonic development. The type I OSM receptor is capable of transducing OSM-specific signaling events. |
